Background: The most prevalent primary liver malignancy is hepatocellular carcinoma (HCC). Soluble platelet-derived growth factor receptor-beta (sPDGFR-β) is a critical factor in the identification of HCC, providing the maximum diagnostic value, when combined with age, creatinine, and alpha-fetoprotein (AFP) levels in the APAC Score. Aim of the work: to evaluate the diagnostic utility of serum sPDGFR-β levels and the significance of the APAC score in the early identification of HCC in Egyptian patients suffering from liver cirrhosis caused by the hepatitis C virus. Patients and Methods: This cross-sectional study included 40 HCV cirrhotic patients without HCC and 40 HCV cirrhotic patients with HCC. Serum PDGFR-β (pg/ ml ) by ELISA was done for all patients. Results: The cirrhosis without HCC group exhibited a significantly higher PDGFR-β level than the cirrhosis with HCC group (mean = 1186.4 ± 544.1 vs. 565.8 ± 297.7 pg/ml, p |
