Objectives
The aim of this study was to investigate the role of lymph node yield (LNY), lymph node ratio (LNR), and neutrophil to lymphocyte ratio (NLR) as prognostic factors, their impact on survival in patients with advanced laryngeal squamous cell carcinoma (LSCC).
Methods
This multicentric retrospective study included 195 patients with clinical N0 advanced laryngeal carcinoma who underwent total laryngectomy and/or total pharyngolaryngectomy over 5 years. The number of lymph nodes extracted (LNY) and the number of positive nodes were counted. The lymph node ratio “LNR” was calculated as follows: (positive nodes /LNY). Moreover, neutrophil to lymphocyte ratio (NLR) was calculated and documented for analysis.
Results
The mean 5-years DFS and overall survival (OS) was 33 and 35 months. The following were statistically significant factors negatively associated with overall survival; LNR (p = 0.047), NLR > 7 (p = 0.05), preoperative tracheostomy (p = 0.016), infiltrated safety margin (p = 0.01), postoperative radiotherapy (p |
