SARS-CoV-2 infection may lead to olfactory dysfunctions affecting patients' quality of life. Despite various ongoing studies, solid evidence supporting therapies, especially for COVID-19-related olfactory dysfunction, remains scarce. To assess nasal steroid, nasal vitamin A, and intranasal theophylline as treatment options for post-COVID-19 olfactory dysfunction. This is a multi-center retrospective case-controlled study of 120 cases with post-COVID-19 olfactory dysfunction (hyposmia or anosmia) at Benha University Hospitals, Egypt, and Dallah Hospital, Riyadh City, Kingdom of Saudi Arabia (KSA) between January 2020 and December 2022. 43.3% males and 56.6% females with median age was 38.5 years. Nasal steroid, nasal vitamin A, and intranasal theophylline had a significantly reduced time for complete smell recovery (25.7 ± 9.20 days, 24.8 ± 6.67 days. 23.5 ± 7.13 days Respectively) in comparison to the control group (olfactory training alone) (28.97 ± 4.29 days) (P = 0.02*). No significant correlation between age, gender, severity, duration of COVID-19 illness, and obesity with anosmia/hyposmia duration and smell scores, however a highly significant negative correlation between diabetes, hypertension, smoking, and asthma complete smell recovery within four weeks of treatment (P-Value |
