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Ass. Lect. Nora Sobhy Mohamed Elhagrsy :: Publications:

Synthesis of Novel Series of Phthalazine Derivatives as Potential Antitumor Agents
Authors: Ashraf Farouk Wasfy *, Aly Abdelmaboud Aly, Mohamed Sayed Behalo, Nora Sobhi Mohamed
Year: 2013
Keywords: : Phthalazin-1-(2H)-One; chlorophthalazine; isoindol-1,3-dione; antitumor activity.
Journal: Chemical and Process Engineering Research
Volume: 10
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Nora Sobhy Mohamed Elhagrsy_phthalazine 1,4-.pdf
Supplementary materials Not Available

A novel series of phthalazine derivatives bearing isoindol-1,3-dione moiety were synthesized by treating 2-[4-(4chlorophthalazine-1-yl)phenyl]-1H-isoindole-1,3-(2H)-dione 3 with various chemical reagents.The newly synthesi- zed compounds were characterized on the basis of their spectral (1H NMR, 13C NMR, Ms, IR) analyses. In vitro, most of the synthesized derivatives were screened for their antitumor activity against HepG2 cells using MTT assay. Compounds 11, 18 and 19c showed the most potent cytotoxic effect concluded from their IC50 values 217.4, 240.3 and 234.5 µg/ml respectively.

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