Background: Widespread physical pain, exhaustion, psychological disorders, and sleep problems are the hallmarks of fibromyalgia (FM), a chronic illness.Quercetin (Qrct) possesses anti-inflammatory and anti-oxidant qualities.
Objective: This study used a reserpine-induced FM rat model to assess Qrct's efficacy in reducing pain, anxiety, and depression.
Method: Three groups of thirty male rats were used: control, RES, and RES + Qrct. Tail flick latency and rotarod tests were used to measure pain, whereas the open field, elevated plus maze, and forced swim tests were used for behavioral evaluations. Neurotransmitters, antioxidants, pro-inflammatory cytokines, and the expression of the NF-kB and CGRP genes were all examined in brain homogenates. The cerebral cortex's histopathological analysis evaluated indicators of apoptosis and inflammation.
Results:The treatment of Qrct enhanced behavior and decreased discomfort, according to the results. This was associated with elevated SOD and IL-10 and decreased MDA and TNF-α levels. Furthermore, Qrct reduced the expression of the NF-kB gene and CGRP.
Conclusion: Qrct's antioxidant, anti-inflammatory, neuroprotective, and anti-apoptotic qualities reduce FM symptoms, suggesting that it may be used as a treatment for FM.
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