Background: Diminished ovarian reserve is increasingly
reported in young women as well, it is an important cause
of infertility. Widespread screen use and artificial lighting
have increased exposure to blue light in the shortwavelength range, which may threaten ovarian reserve
(OR). Growth hormone (GH) may counteract this injury by
modulating the insulin‑like growth factor‑1/insulin‑like
growth factor‑1 receptor (IGF‑1/IGF‑1R) axis. Aim: To
evaluate the impact of blue light on OR and determine
whether GH protects the ovary through IGF‑1/IGF‑1R
restoration. Methods: After 7 days of acclimatization,
twenty‑four prepubertal female rats were randomized into
four groups (n = 6) for a 10‑day experiment: control
(natural room light, saline subcutaneous (s.c.) once daily
from day 4 to day 10); GH (natural room light, GH 1 mg/kg
s.c. from day 4 to 10); blue light (450–480 nm for 12
h/night, 6:00 p.m.–6:00 a.m., from day 1 to day 10 plus
saline s.c. from day 4 to 10); and blue light + GH (same
light protocol plus GH 1 mg/kg s.c. from day 4 to 10). On |
