Background Sodium fluoride (F) is ubiquitously present in the environment and affects animals’ and humans’ health.
Nannochloropsis oculata (NO) is a microalga that contains bioactive components with a preferential anti-inflammatory
and antioxidant action. This study aimed to assess the tenable protective role of NO and nano-gold (AuNO) extracts
toward F-evoked toxicity in rats.
Methods Six groups of male rats were assigned. The CTL (control) group was given distilled water; the NO group, rats
were given NO extract (250 mg/kg b.w.), and AuNO group, rats received 500 mg/kg b.w of AuNO extract. Further, F
group was given F (30 mg/kg b.w). NO+F group, and AuNO+F rats were administered with a combination of AuNO
and F.
Results F exposure caused noteworthy and significant oxidative stress and apoptosis. Additionally, there is a highly
significant major regulation of proinflammatory genes and proteins. Furthermore, F significantly downregulated the
kidney’s aquaporins, which can be used to identify renal impairment early. F-triggered damage was considerably
reduced by pretreatment with both algal extracts.
Conclusions Our findings support NO supplemen |
