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Prof. Aly Abdel Maboud Aly :: Publications:

Synthesis of quinazoline derivatives as potential antimicrobial agents
Authors: Mohamed S. Behalo*, Abdelmotaal Abdelmajeid*, Aly A. Aly, Kaouser A. Hebash and Enas A. Mohamed
Year: 2015
Keywords: Benzoxazinone, quinazolinone, amino acids, antimicrobial activity
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Not Available
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An efficient synthesis of substituted quinazoline derivatives was achieved from the reaction of 2-((1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)methyl)-4H-benzo[d][1,3] oxazin-4-one (3) as a reactive starting material with variety of nucleophilic reagents. The Structural formula of all derivatives were confirmed and characterized by elemental analysis and spectral data. Some of the synthesized compounds were also screened for their antibacterial and antifungal activities and compared with standard drugs. Most of the tested compounds showed potent to weak antimicrobial activities.

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