The purpose of this study was carried to evaluate the protective and anti-inflammatory effect of
ginger against metalaxyl toxicity induced liver damage and oxidative stress in rats. Forty two male
albino rats were divided into three equal groups. Group I (normal group): rats administered distilled
water. Group II (metalaxyl exposed group): rats received metalaxyl 1/10 LD50 (130 mg/kg b.wt)
orally three times per weeks for 8 weeks. Group III (metalaxyl + ginger treated group): rats received
metalaxyl (130 mg/kg b.wt) and treated with ginger (100 mg/kg b.wt/day/orally). The obtained
results showed significant increase in serum hepatic function enzymes (ALT, AST and ALP)
activities, hepatic tissue L-MDA levels and inflammatory biomarkers (MPO and IL-6) in metalaxyl
exposed rats. However, activities of liver tissue antioxidant enzymes (SOD, CAT) and GSH
concentration were markedly decreased. Administration of ginger with metalaxyl exposed rats
caused significant improvement of all previous parameters towards its normal ranges. These results
suggested that, ginger treatment may have a protective effect against liver damage and oxidative
stress in rats through free radical scavenging and anti-inflammatory activity as well as regenerating
endogenous antioxidant defense system mechanisms. |
