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Prof. Samy Ali Hussein Aziza :: Publications:

Title:
Curcumin ameliorates Ethanol induced Gastric Mucosal Erosion in Rats via alleviation of Oxidative Stress and Regulation of Pro-Inflammatory Cytokines and NF-kappa B activation
Authors: Samy Ali Hussein, Mohamed M. Karousa, Aziza Amin and Maher A. AwadallaSamy Ali Hussein1*, Mohamed M. Karousa2, Aziza Amin3 and Maher A. Awadalla1Samy Ali Hussein1*, Mohamed M. Karousa2, Aziza Amin3 and Maher A. Awadalla1
Year: 2016
Keywords: Curcumin; Gastritis; Apoptosis; Pro-inflammatory Cytokines; NF-kappa B, oxidative stress; histopathology.
Journal: International Journal of Chemical and Natural Science
Volume: 4
Issue: 4
Pages: 466-476
Publisher: Aizeon publishers
Local/International: International
Paper Link:
Full paper Samy Ali Hussein Aziza_ijcns466-476.pdf
Supplementary materials Not Available
Abstract:

The present study was undertaken to evaluate the potential protective and therapeutic effect of curcumin (Cur) on ethanol-induced gastritis in rats. Fourty male albino rats were divided into four groups. Group Ι: (Control group): received no drugs. Group Π: (Gastritis non-treated group): administered with a single oral dose of 1 ml/rat of absolute ethanol for gastritis induction. Group III: (Gastritis + Cur protected group): received Cur (100 mg/kg body weight/day) orally for 14 days prior ethanol administration. Group IV: (Gastritis + Cur treated group) received Cur as in group III and the treatment was continued for 7 days later. The obtained results showed a significant decrease in serum nitric oxide (NO), sialic acid (SA), and gastric tissue GSH, vitamin C concentrations and GPX, SOD, GR and CAT activities in gastritis induced rats. However, myeloperoxidase (MPO) and cyclooxygenase II (COX-2) activities, NF-KB p65, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1beta (IL-1β), L- Malondialdehyde (L-MDA) and DNA-fragmentation were significantly increased. Administration of Cur was able to mitigate gastritis induced by ethanol through increasing of NO, SA, GSH, vitamin C concentrations, GPx, SOD, GR, CAT activities in addition to decreasing NF-KB p65, TNF-α, IL-6, IL-1β, L-MDA, DNA-fragmentation and MPO as well as COX-2 activities. Furthermore, various pathological changes in gastric tissues were observed in gastritis induced rats. Interestingly, the severity of these alterations was reduced in curcumin protected and treated groups with variable degree. These results suggest that, Cur may be beneficial in treatment of gastritis by its radical scavenging and antiapoptotic activity, reserved inflammation, oxidative stress and regulate NF-kappaB activation and attenuate the severity of histopathological alterations in the gastric mucosa

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