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Prof. Samy Ali Hussein Aziza :: Publications:

Title:
Evaluation of Gastroprotective Effect and Anti-Inflammatory Role of Resveratrol against Gastric Mucosal Alterations in Experimental Model of Gastritis in Rats
Authors: Samy Ali Hussein , Mohamed M. Karousa , Aziza Amin and Maher A. Awadalla
Year: 2016
Keywords: Resveratrol; Gastritis; inflammatory markers; oxidative stress; antioxidant status, histopathology.
Journal: International Journal of Pharma Sciences
Volume: 6
Issue: 3
Pages: 1559-1570
Publisher: aizeon publishers
Local/International: International
Paper Link:
Full paper Samy Ali Hussein Aziza_ijps1559-1570(1).pdf
Supplementary materials Not Available
Abstract:

Resveratrol is a phytoalexin polyphenol exhibiting antioxidant and anti-inflammatory properties. The present study was designed to evaluate the potential protective and therapeutic effects of resveratrol (RSV) on ethanol-induced gastritis in rats. Thirty two male rats divided into four groups. Normal control group: received no drugs, gastritisinduced group: administered with a single oral dose of 1 ml/rat of absolute ethanol, gastritis + RSV protected: received RSV orally (10 mg/kg b. wt/day) for 2 days prior ethanol administration and gastritis + RSV treated: received RSV as in group III and the treatment was continued for 7 days later. Blood samples and gastric tissue specimens were collected for determination of serum and gastric tissue parameters. The obtained results showed a significant decrease in serum nitric oxide (NO), sialic acid (SA), and gastric tissue GSH, vitamin C concentrations and GPX, SOD, GR and CAT activities in gastritis induced rats. However, myeloperoxidase (MPO) and cyclooxygenase II (COX-2) activities, NF-KB p65, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1beta (IL- 1β), L- Malondialdehyde (L-MDA) and DNA-fragmentation were significantly increased. Administration of RSV was able to mitigate gastritis induced by ethanol through increasing of NO, SA, GSH, vitamin C concentrations, enzymatic antioxidants status in addition to decreasing NF-KB p65, Pro-inflammatory cytokines, L-MDA, DNAfragmentation, MPO and COX-2. Additionally, various pathological changes in gastric tissues were observed in gastritis induced rats. Interestingly, the severity of these alterations was reduced in resveratrol protected and resveratrol treated groups with variable degree. The results suggest that, RSV may be effective in the therapeutic of gastritis by its radical scavenging and antiapoptotic activity, inhibited neutrophil accumulation, restoring endogenous antioxidant mechanisms and attenuate the severity of histopathological alterations in the gastric mucosa.

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