This work aimed to study is the effect of certain antidepressant drugs such as Amitriptyline (Tricyclic antidepressant), Maprotiline (Heterocyclic antidepressant), and fluoxetine (serotonergic agent) on some brain and liver enzyme activities .Sixty male New-Zealand rabbits , were randomly divided into 4 groups each of 15 rabbits as follow:Group I: (Control rabbits) Group II: received Amitriptyline (3.5 mg/kg body weight)orally and daily for 4 weeks., Group III: administered with Maprotiline orally daily (2.33 mg/kg body weight) for 4 weeks. Group IV: administered the therapeutic dose of Fluoxetine (0.93 mg/kg body weight) orally and daily for a duration of 4 weeks.The obtained data revealed that, the anti-depressant drugs caused a marked decrease in brain and liver Monoamine oxidase (MAO) activities ,and a very highly significant increase in brain and liver Cholinesterase ( ChE) activity a long the periods of experiment. Regarding Brain and liver alkaline phosphatase (ALP) activity, the btained results demonstrated a highly significant increase in its activity, whereas The obtained results revealed that brain and liver 5' nucleotidase (5'NT) activity showed a highly significant decrease along the experiment. Also The obtained results revealed that Amitriptyline and Maprotiline caused highly significant increase in brain creatine kinase (CK)activity a long the experimental periods. On the other hand, Fluoxetine resulted in significant decrease in brain and liver CK activities |
