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Dr. remah sobhy atia abd elrazek :: Publications: |
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| Title: | The protective effects of geraniin against initial and intermediate carbonyl-induced glycoxidation stress in bovine serum albumin models |
| Authors: | Remah Sobhy, Jianing Zhang, Zhihua Li, Yangyang Jia, Ali Korin, Mahmoud Salah, Mohamed Abdin, Zou Xiaobou |
| Year: | 2025 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
This study elucidates the multi-target anti-glycoxidation mechanisms of geraniin (G), a hydrolysable tannin, using bovine serum albumin (BSA) models incubated with glucose (BSA-G), glyoxal (BSA-GO), and methylglyoxal (BSA-MGO). Through comprehensive analysis employing multispectral analysis, molecular docking, and confocal microscopy, G demonstrated significant inhibitory capacity against advanced glycoxidation end-product (AGEs) formation across three stages. In the early stage, G competitively binds to specific lysine (Lys127–434) and arginine residues (Arg185–456) in BSA-subdomains, effectively reducing glucose-BSA covalent binding by 63 % (at 90 μM G; p |
