Benzoquinazoline derivatives were synthesized and chemically modified to enhance their
antimicrobial activity and performance as cationic surfactants. The target compounds were
obtained via conversion to N-(3-(dimethylamino)propyl)-3-(4-oxo-4H-benzo[d][1,3]oxazin-2-
yl)propanamide, followed by quaternization with fatty alkyl 2-chloroacetates. The synthesized
cationic surfactants possess a quaternary ammonium hydrophilic head and hydrophobic alkyl
chains, The hydrophobic head of an organic heterocyclic surfactant component attracted polar
water, whereas the hydrophobic tail attracted non-polar solvents like oil. As a result, they dissolve
in both polar and nonpolar liquids and are amphipathic. This characteristic has been used to
produce surfactants as emulsifiers, solubilizers, and wetting agents. giving them amphipathic
character. They effectively decrease surface and interfacial tension, show low values of the
critical micelle concentration (CMC). and demonstrate superior aggregation behavior at low
concentrations. These properties make the prepared compounds economically attractive and
suitable for industrial applications. In particular, they show favorable surface activity as effective
emulsifying agents for cosmetic formulations. |
