الصفحة الحالية:الصفحة الرئيسية
د. إيناس عبد العليم السيد محمد الضباش
الدرجة الوظيفية: مدرس
الوظيفة الإدارية الحالية:
الوظيفة الإدارية السابقة:
الكلية: كلية العلوم
القسم: كيمياء
البريد الإلكتروني التعليمي: enas.mohamed@fsc.bu.edu.eg
رقم الموبايل:
الإسم العلمي: Enas A. Mohamed
البحوث [ عناوين(5) :: بحوث كاملة(5) :: ملخصات البحوث(5) ]
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أخبار
New multi-functionalized pyridines: Facile synthesis, anti-cancer evaluation and in silico molecular docking [2025-10-04]
Developing new compounds with bioactivity, especially against tumors, targeting G-quadruplexes is of great importance. In this direction, some new phthalimide-incorporating pyridine derivatives were synthesized using the phthalimido-acetophenone derivative 1 as a key precursor. Three-component cyclocondensation of compound 1 with various aryl aldehydes and ethyl cyanoacetate or malononitrile utilizing ammonium acetate as the nitrogen source afforded the 4-substituted-6-(4-phthalimidophenyl)pyridin-2-one-3-carbonitriles 2a-e or the 2-amino-4- substituted-6-(4-phthalimidophenyl)pyridine-3-carbonitriles 3a,b, respectively. Moreover, the characterization of these derivatives was identified on the basis of elemental analysis and spectroscopic tools. Additionally, the potency of the targeted molecules as anticancer agents was assessed against two carcinogenic human cell lines, namely, colon cancer (HCT-116) and human prostate cancer (PC3) cells. They exhibited promising cytotoxicity in which compounds 2a and 2b have the strongest potency comparable with doxorubicin (Dox). The conducted molecular docking studies revealed a good correlation between the anti-cancer activities of compounds and their binding effectiveness with both c-MYC and KRAS G-quadruplexes. download attachmentmore
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