The current work was designed to study the effects of turmeric
rhizome powder on liver disorders induced by Benzo(a)pyrene
[B(a)P] in rats. Treatment of animals with B(a)P caused a
significant increased (p≤0.05) in AST (72.71%), ALT
(116.67%) and ALP (238.41%) compared to normal controls.
Supplementation of the rat diets with turmeric powder (0.50,
1.00, 1.50, and 2.00 g/100g) prevented the rise of mean serum
AST, ALT and ALP activities. The same behavior was
recorded for MDA, the biomarker of oxidative stress in cells,
levels in serum and xenobiotics metabolizing enzyme i.e.
cytochrome p450 in hepatocytes. The opposite direction was
recorded for the glutathione fractions (biological
macromolecules antioxidant) in serum. These results supported
our hypothesis that turmeric powder contains several categories
of bioactive compounds that are able to prevent/inhibited the
B(a)P induced liver disorders through liver serum enzymeslowering
activity, decreasing rate on the formation of serum |
