Aim: To investigate the intermediate and short-term effects of transcatheter secundumatrial septal defect (ASD) closure on cardiac remodeling in children and adult patients.
Methods: 50 patients with secundum ASD referred for possible transcatheter device closure were subjected to history taking; proper physical examination; electrocardiographic assessment and transthoracic echocardiographic examination and were evaluated before the ASD closure, 1 day, 3m and 6m after closure.
Conclusion: Transcatheter ASD device closure leads to significant improvement in right sided chambers dimension and function and can reverse electrical and mechanical changes in atrial and ventricular myocardium in children and adults in short and intermediate term follow up.
Results: At the 6 month follow up electrocardiographic parameters of remodeling improved so P dispersion decreased from 49.73 ± 9.01to 30.53 ± 5.08 ms (p = 0.004), QT dispersion decreased from 67.6 ± 5.31 to 51.13 ± 5.73 ms (p = 0.003), QRS duration decreased from 134.4 ± 4.97 to 116.20 ± 3.47 ms(p = 0.002) , PR interval decreased from 188.87 ± 6.06 to 168.00 ± 6.16 ms (p = 0.002).At the end of follow-up period of 6 month, RVEDD had decreased from 25.67 ± 5.50 mm to 17.80± 2.7 mm (p = 0.001), and the LVEDD had increased from 33.17 ± 6.44 to 37.53 ± 5.15 mm (p = 0.002), Mean PAP decreased from 16.97 ± 3.37 to 9.22 ± 1.37 mmHg (p = 0.000), RVSP decreased from 30.77 ± 4.69 to 18.8 ± 2.11 mmHg. After 6m 93.3% of the patients had normal RV size.
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