Abstract Objectives: To test the safety of sildenafil in patients with stable coronary artery disease
(CAD).
Methods: Sixty-one patients with stable CAD, documented by coronary angiography were
included in this phase I study. Patients were randomized to either single dose sildenafil or matched
placebo. Speckle tracking echocardiography was done at baseline and 60 min after sildenafil/placebo
intake to calculate peak systolic strain (PSS) of the most severely affected myocardial segments
and the global longitudinal PSS.
Results: The baseline mean segmental PSS in the sildenafil group changed by 52%, 3± 1% at
baseline versus 7± 2% after sildenafil intake, P =0.01. However, no significant changes were
reported in the placebo group, 7± 3% at baseline versus 7.25 ± 3%, P = 0.1. The baseline
mean global longitudinal PSS in the sildenafil group changed by 9% (15 ±4% at baseline versus
18 ± 3% after sildenafil, P =0.03). In placebo patients, the change was only 3% from baseline
(14.8 ± 2% at baseline compared to 15 ± 2% after placebo intake, P = 0.1). Sildenafil was
well tolerated without clinical or hemodynamic deterioration after its intake.
Conclusion: Sildenafil intake is safe in patients with stable CAD, it induced marginal improvements
in the peak systolic strain of different myocardial ischemic territories. |
