You are in:Home/Publications/Effect of Rosuvastatin on high salt induced cardiac hypertrophy and susceptibility to isoprenaline induced cardiac infarction in albino rats.

Dr. Samia Mahmoud Mohamed Elshiaty :: Publications:

Title:
Effect of Rosuvastatin on high salt induced cardiac hypertrophy and susceptibility to isoprenaline induced cardiac infarction in albino rats.
Authors: Mohie Al-Dien Elsayed Sherirf , Samia El-Sheity and Ahmed Abu-Elmatty Algzar
Year: 2008
Keywords: Not Available
Journal: rats. Egyptian Society of Pharmacology and Experimental Therapeutics J.
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Not Available
Supplementary materials Not Available
Abstract:

Abstract Rosuvastatin is a new synthetic and chemically distinct member of the statin family. Clinical evidence has shown that rosuvastatin is the most effective statin with regard to lipid lowering. However, whether rosuvastatin possesses the ability to exert similar, or more significant, beneficial effects on cardiovascular remodeling is yet to be established. The aim of this work is to evaluate the effect the rosuvastatin on High salt induced cardiac hypertrophy and also isoprenaline induced myocardial infarction on top of this hypertrophy. Myocardial infarction is induced (after 8 weeks) by subcutaneous injection of isoproterenol 20 mg / 100 g body weight .The following parameters were defined: 1) Levels of the marker enzymes such as Creatine Kinase CPK, Lactate dehydrogenase, LDH, in serum.. 2) T wave elevation. 3) Lipid peroxide, thiobarbituric acid reactive substances (TBARS) as a parameter to lipid oxidation and, Superoxide dismutase (SOD) in cardiac homogenate. Rosuvastatin proved to abolish cardiac hypertrophy induced by High salt diet and cause cardioprotection against isoprenaline induced myocardial infarction.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus