Abstract: Background: (1) Th aims of this study are to investigate the glycemic efficy and predictive parameters of
DPP IV inhibitors therapy in Egyptian subjects with type 2 diabetes. (2) Investigate the level and the determinants
that affect the secretion of glucagone like peptide-1(GLP-1) in Type2 diabetic patients. Subjects and Methods:
This study was conducted on 70 type 2 diabetes patients【35 males & 35 females】 under known antidiabetic drugs,
Their ages range was (30-63y) and average mean (46.31±10.75 y), as well as 20 apparently healthy subject's
volunteers served as control 【12 males & 8 females】 with age range (28-50y) and SD (37.40±5.04 y). DPP-4
inhibitors were added to every patient after the start of the study. The patients were followed at monthly interval for
3 months after the beginning of DPP-4 inhibitors therapy. Results: GLP-1 levels were significantly decreased in
DM subjects compared to controls (261.33± 9.37 vs.75.48 ± 20.81pg/mL, p |
