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Prof. Rajaa Mostafa El-Belashy :: Publications: |
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| Title: |
FOETUSES ABNORMALITIES CAUSED BY TEGRETOL DRUG ON THEIR PARENTS OF THE ALBINO RAT
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| Authors: | El-Balshy R.M, Zowail M.E, Nafie E.H and El-Feky M.A. Zoology Department, Faculty of Science, Benha University, Egypt. |
| Year: | 2022 |
| Keywords: | Tegretol, Endoskeleton System, Histopathology, Teratogenicity, 20-Day-Old Albino Rat Foetuses |
| Journal: | International Journal of advanced Research |
| Volume: | 10 |
| Issue: | 1 |
| Pages: | 397-417 |
| Publisher: | Prof.Dr.Ragaa Mustafa El-Balshy |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
The current study was performed to illustrate the harmful effects of different doses of Tegretol (CBZ) which has active ingredient (Carbamazepine; CBZ) on the prenatal foetuses of rat at 20th day of gestation. Tegretol (CBZ) noticeably reduced the body weight &length of foetuses in addition the percentage of dead foetuses increased; the early mortality of foetuscs which became resorbed besides late foetuses mortality (stillbirth) during the gestation phase. Tegretol (CBZ) administration caused delay of ossification of some bones and shortness of others. Some histo-pathological alterations were founded in livers, kidneys, and lungs of foetuses tissues which parentally administered with different doses of Tegretol (CBZ). |
