Background: Colorectal cancer (CRC) is the third leading cause
of cancer death in the world. Precancerous lesions that may
progress to CRC include inflammatory bowel disease (IBD) and
adenoma This study aims to clarify the role of STMN1 and
ACeCS2 and the morphometric changes in colorectal
carcinogenesis. Material and methods: This is a retrospective
study on 100 cases; control (n=8) IBD (n=29), convetional
adenoma (n=19), serrated polyp/adenoma (n=9) and CRC
(n=35), All cases were stained with STMN1 and ACeCS2
antibodies using Avidin-biotin complex. In morphometry, we
assessed nuclear morphometric parameters and gland/stromal
ratio among studied groups. Results: There was statistically
significant correlation between Stathmin-1 and dysplasia in IBD
(p=0.008), with dysplasia (p=0.05), types (p-0.003) of
conventional adenoma, staging (p=0.015) and node metastasis
(p=0.04) of CRC cases. There was statistically significant
correlation between ACeCS2 among studied groups (p=0.006),
with dysplasia in IBD (p=0.002), staging (p=0.001) and node
metastasis (p=0.004) of CRC. There was statistically significant
correlation between morphometric parameters among studied
groups (P |
