Background: The study was done to project the important role of the anti-inflammatory
and anti eoxidant properties of Ascorbic acid (vitamin C) in reducing the incidence of
atrial fibrillation (AF) in the early post-operative period after coronary artery bypass graft
operation (CABG).
Methods: This prospective randomized study included 100 patients admitted to cardiothoracic
surgery department, Benha University Hospital, Benha, Egypt between 2011 and
2016. Those patients scheduled for CABG, were randomized into two groups of patients:
the first; group 1: A fifty CABG patients were given b -blocker (bisoprolol 5 mg o.d.) &
ascorbic acid (2 g daily in divided doses qds) for at least three days pre-operatively. The
second; group 2: A fifty CABG patients were given b -blocker (bisoprolol 5 mg o.d.) for at
least three days pre-operatively. Patients were followed up for AF after (CABG) for the
short term of 3 weeks.
Results: The incidence of AF after CABG in1st 48 h and after 1 month was statistically
significantly lower in Group 1 than Group 2 with p value 0.022 and 0.025 respectively.
Intensive care unit stay, need for inotropic support and ventilator stay were also significantly
decreased in Group1 than Group 2 with p value 0.035, 0.045 and 0.048 respectively.
Conclusions: The incidence of post CABG AF, intensive care unit stay, need for inotropic
support and ventilator stay were decreased by patients intake of vitamin C in combination
with b -blockers pre-operatively.
© 2017 The Egyptian Society of Cardio-thoracic Surgery. Publishing services by Elsevier B.V.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/
licenses/by-nc-nd/4.0/). |
