The pharmacokinetic parameters of ceftriaxone in blood, urine and
milk following intravenous and intramuscular (single & repeated)
administrations were estimated in normal and experimentally
Salmonella typhimurum infected goats. Following a single intravenous
injection of 20 mg ceftriaxone/kg b.wt. in normal goats, ceftriaxone
could be detected therapeutically for 8 hours post intravenous
injection. The serum concentration – time curve of ceftriaxone
following intravenous injection showed that the drug obeyed a two
compartments open model. The intramuscular bioavailability of
ceftriaxone in normal goats was 61.28%. Intramuscular injection of 20
mg ceftriaxone per kilogram body weight twice daily for five
consecutive days in normal and Salmonella typhimurium infected
goats revealed a lower significant serum ceftriaxone concentration after the first, third, fifth,
seventh, ninth doses in Salmonella typhimurium infected goats compared with normal goats..
The high milk concentrations of ceftriaxone in lactating goats after repeated intramuscular
administrations, suggested that ceftriaxone could be used for treatment of mastitis caused by
Salmonella typhimurium and other sensitive microorganisms to ceftriaxone in lactating goats.
The high concentrations of ceftriaxone in urine after repeated intramuscular administrations,
suggested that ceftriaxone is a suitable antimicrobial for treatment of urinary tract infections
caused by Salmonella typhimurium and other sensitive microorganisms to ceftriaxone in
goats.
|
