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Dr. Mona Kamal El-Awam :: Publications: |
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| Title: | An emerging role of Beclin-1-mediated autophagy in the cardioprotective impact of
Lactobacillus acidophilus in diabetic hyperlipidemic rats beside the antioxidant and antiinflammatory potency |
| Authors: | Walaa H.Mohammed1 , Mona K. Alawam1 , Israa H. Khairat2 ,Sania K. Elwia3 , Marwa Said El-sayed4 , Mahmoud M. Hassan1 , Marwa H. Muhammad1* |
| Year: | 2025 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Mona Kamal El-Awam_paper 4 An emerging role of Beclin-1-mediated autophagy in the cardioprotective impact of Lactobacillus.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Background: Cardiac dyshomeostasis is steadily increasing in obese diabetics, with growing evidence pointing to a potential connection between diabetic cardiomyopathy (DCM) and gut microbiota alterations. The probiotic Lactobacillus acidophilus (Lacto-B) has garnered significant interest for its beneficial properties. This study aimed to explore the mechanisms by which LactoB exerts its protective effects and to assess the role of beclin-1-mediated autophagy in DCM. Method: Twenty-four rats were grouped into Control, Lacto-B, high-fat diet (HFD), and HFD + Lacto-B, for 8-week experimental period. Lacto-B was administrated at a dose of (2 x 108 ) colony-forming units/ml/d by oral gavage. Echocardiographic, biochemical, and microscopic evaluations for cardiac changes were assessed. Glycemic and lipid profiles, oxidative stress, inflammatory markers nuclear factor-кB, interleukin-1β, interleukin-10, and beclin-1 protein were evaluated |
