Purpose: to assess safety and efficacy of
autologous mesenchymal bone marrow stem
cell injection in penile cavernosal tissue for erectile dysfunction
therapy in diabetic men.
Methods: The subjects of this study were diabetic men suffering
erectile dysfunction, non-responding to maximum dose of oral
PDE5I. Mesenchymal bone marrow stem cells were aspirated
and injected after preparation in both corpora cavernosa at 3, 9
o’clock position. Erectile function was assessed by the
International Index of Erectile Function and penile Doppler
study, before and after 6 months after injection.
Results: 4 patients out of 10 achieve hard erection adequate for
satisfactory coitus, and 2 patients achieved penile hardness
with addition of pharmacological therapy with sildenafil
100mg. Peak systolic velocity increased significantly in 4
patients (2 arteriogenic and 2 mixed erectile dysfunction), from
12∼22 cm/s to 32∼69 cm/s. Variations in end-diastolic velocity
increased substantially in 2 patients with venogenic insufficien-
cy alone at follow-up from 4∼5 cm /s to -4∼-3 cm/s.
Conclusions: Despite promising stem cell treatment efficacy for
patients with erectile dysfunction, more clinical studies and
researches are still warranted. |
