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Dr. Mohamed Elbadawy Abdelgayed Gad Kewan :: Publications: |
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| Title: | Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. |
| Authors: | Mohamed Elbadawy, Tatsuya Usui, Hideyuki Yamawaki and Kazuaki Sasaki |
| Year: | 2018 |
| Keywords: | MAPK; DAPK; ERK; p38; JNK |
| Journal: | Int J Mol Sci. |
| Volume: | 19 |
| Issue: | 10 |
| Pages: | 3031 |
| Publisher: | MDPI |
| Local/International: | International |
| Paper Link: | |
| Full paper | Mohamed Elbadawy Abdelgayed Gad Kewan_Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals..pdf |
| Supplementary materials | Not Available |
| Abstract: |
Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the roles and regulatory mechanisms of DAPK family members and their relevance to diseases. Furthermore, a special focus is given to several reports describing cross-talks between DAPKs and mitogen-activated protein kinases (MAPK) family members in various pathologies. We also discuss small molecule inhibitors of DAPKs and their potential as therapeutic targets against human diseases. |
