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Dr. Marwa Elsayed Mohamed Elnagar :: Publications:

Title:
Diagnostic value of calprotectin in differentiation between benign and malignant pleural effusion
Authors: Omar M Mohammed, Kamel M Hussein, Abdelgawad E Ramadan, Gouda T Mahmoud, Marwa El-Sayed El-Naggar, Nor Eldein Z Gaber
Year: 2020
Keywords: Not Available
Journal: Egyptian journal of bronchology
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link:
Full paper Marwa Elsayed Mohamed Elnagar_7.pdf
Supplementary materials Not Available
Abstract:

Background Pleural effusion can arise as a result of more than 50 recognized causes and the differentiation between benign and malignant origin of the fluid is still a diagnostic challenge. The ability of tumor markers and other biological markers to make better diagnosis of malignant pleural effusion (MPE) remains questionable. Out of these, the calcium-related proteins S100-A8 and S100-A9 (the noncovalent heterodimer calprotectin) were demonstrated in a small amount in malignant not in benign pleural effusion. Objectives This research aimed to assess the diagnostic value of calprotectin in the differentiation between infectious or benign and MPE. Patients and methods Sixty patients were divided into group I: malignant and group II: infectious pleural effusions (which were further divided into group IIA: parapneumonic effusion and group IIB: tuberculous effusion) Quantitative measurement of calprotectin was done using the enzyme-linked immunosorbent assay technique in pleural effusion. Results Pleural calprotectin level in MPEs (229.2±168.6 ng/ml) was significantly lower than its level of infectious pleural effusions (3202.2±1304.8 ng/ml; P

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