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Ass. Lect. Manar Ahmed Metwally Ahmed Elfakahany :: Publications:

Title:
A unified nonlinear mathematical model for Beta-CoV
Authors: Manar Ahmed Elfakahany,Mahmoud Adel Hassan,Mona A. Bayoumi, Omar M. Salim
Year: 2025
Keywords: Coronavirus Describing Function Nonlinear, SARS-CoV-2, Virus Clearance, Virus Production, Sensitivity Analysis
Journal: Biomedical Signal Processing and Control
Volume: 110
Issue: Not Available
Pages: 108-144
Publisher: ELSEVIER
Local/International: International
Paper Link:
Full paper Manar Ahmed Metwally Ahmed Elfakahany_A unified nonlinear mathematical model for Beta-CoV.pdf
Supplementary materials Not Available
Abstract:

COVID-19 is a new deadly virus caused by the SARS-CoV-2 coronavirus, first identified in China at the end of 2019. Mathematical modeling is one of the most operative ways to comprehend and manage the growth of such viruses. However, existing models have limitations, including challenges in mathematical analysis and a tendency to represent each virus individually. In this paper, a unified mathematical model is proposed to describe the dynamics of Beta-CoV viruses in the human body, providing insights into their spread and control. This model is adaptable to multiple coronaviruses, including MERS, SARS-CoV-2, COVID-19, and Omicron. The model parameters are carefully adjusted to ensure suitability for each Beta-CoV variant. The stability of the proposed model is analyzed using the Describing Function nonlinear technique. Additionally, the incubation periods of different Beta-CoV viruses are investigated to determine which has the shortest duration in the human body. The model is further extended to study the impact of antiviral drugs on viral dynamics. Finally, a sensitivity analysis is conducted to identify the most influential parameters affecting viral behavior, which can help in developing targeted interventions.

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