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Dr. Mahmoud Hamdy Rizk :: Publications: |
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| Title: | Plasma Osteopontin Level and Nonalcoholic Fatty Liver Disease in
Patients with Type 2 Diabetes Mellitus |
| Authors: | Mahmoud Rizk*, Mohamed Ahmed El Assal, Mohammed Awad Sakr, Ahmed Refaat Mohammed, Mohamed Abd Ellatif Afifi |
| Year: | 2023 |
| Keywords: | Keywords: Osteopontin, NAFLD, Type 2 diabetes mellitus. INTRODUCTION One of the most common causes of chronic liver disease (CLD) in the globe is NAFLD. In the absence of alcohol misuse, drug adverse effects, or viral hepatitis, NAFLD is characterised by an increased intrahepatic triglyceride (TG) concentration, with or without inflammation and fibrosis (1). Steatosis alone, which is often benign, can advance to steatohepatitis, which has inflammation and fibrosis, followed by cirrhosis, liver failure, and in rare circumstances, hepatocellular cancer. Obesity, DM, and metabolic syndrome are frequently linked to NAFLD. It is regarded as a component of the metabolic syndrome as well (2). T2DM is characterised by hyperglycemia brought on by a variety of pathophysiological elements, most notably insulin resistance and insufficient insulin production. Diabetes patients are more likely to experience accelerated atherosclerosis, which can lead to coronary artery disease, peripheral artery disease, and cerebrovascular diseases, all of which have a significant negative impact on morbidity and mortality(3). Diabetes is expected to be substantially more common in NAFL and nonalcoholic steatohepatitis (NASH) patients than in the general population (8.5%), with prevalence rates of 22.51% and 43.63%, respectively (4). Inflammation, immunity, angiogenesis, fibrogenesis, and |
| Journal: | The Egyptian Journal of Hospital Medicine |
| Volume: | Vol. 92, Page 6480- 6487 |
| Issue: | Vol. 92, Page 6480- 6487 |
| Pages: | Vol. 92, Page 6480- 6487 |
| Publisher: | Egypt's Presidential Specialized Council for Education and Scientific Research, with the Faculty of Medicine at Ain Shams University |
| Local/International: | International |
| Paper Link: | |
| Full paper | Mahmoud Hamdy Rizk_OSTEOPONTIN.pdf |
| Supplementary materials | Not Available |
| Abstract: |
ABSTRACT Background: Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are frequently linked. NAFLD has grown to be a major health problem. A glycoprotein called osteopontin (OPN) has been linked to the aetiology of NAFLD. Objective: This study aimed to determine if there is a connection between the level of plasma OPN and the occurrence of NAFLD in people with T2DM. Patients and Methods: This case-control study was conducted in the outpatient clinic of Internal Medicine Department at Benha University Hospital through the period between November 2022 and April 2023. It included 138 participants divided into three groups: Group 1 included 46 patients with NAFLD and T2DM, group 2 included 46 patients with NAFLD without T2DM, and group 3 that contained 46 healthy individuals as control group. Results: There were significantly higher plasma OPN concentrations in both groups 1 and 2 than in group 3. OPN levels were higher in group 1 compared to group 2. A positive correlation was found between OPN and body mass index (BMI) in both NAFLD groups. In group 2, plasma OPN correlated positively with uric acid and high-density lipoproteins (HDL) levels, while a negative correlation was observed with systolic blood pressure (SBP). Conclusion: Patient's with NAFLD and T2DM had higher plasma OPN levels more than those without diabetes who have NAFLD. Additionally, our study showed a favorable association between plasma OPN level and BMI, uric acid (UA), and HDL, suggesting that plasma OPN may have a role in the adjustment of the metabolic state. |
