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Prof. Mahmoud mohamedabdelrahman elsalhy :: Publications:

Title:
mannose binding lectin in patients with pulmonary Tuberculosis: active and inactive
Authors: Mahmod M. elsalahy ,Gehan , Rasha hendy
Year: 2017
Keywords: Not Available
Journal: Egyptian journal of chest diseases and tuberculosis
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link:
Full paper Mahmoud mohamedabdelrahman elsalhy_11.pdf
Supplementary materials Not Available
Abstract:

This study was done to assess the relation between serum mannose binding lectin (MBL) and disease activity and extension in patients with tuberculosis. Methods The study included 50 pulmonary TB cases recruited from chest department at El Abasia and Tanta Chest Hospitals and 27 patients with other respiratory infections as a positive control group. Also 13 healthy subjects were included as a negative control group. Patients were classified as follows: 30 with active TB (group I), 20 with inactive TB (group II) and 27 with non-TB respiratory diseases as positive control group (group III). Full clinical evaluation, plain chest X-ray (postero-anterior & lateral views), routine laboratory investigations were done to all patients. MBL measurement in serum of all subjects was done by an ELISA assay. Results No significant difference in MBL levels seen between males and females in all studied groups. MBL levels were significantly higher in group I & II than the other groups. MBL levels were non-significantly higher in active TB (group I) than inactive TB (group II) while they were significantly higher in active TB cases than in infectious respiratory diseases other than TB and non-infectious respiratory diseases. Levels were non-significantly higher in active TB cases than in controls. MBL levels were significantly higher in TB cases than in infectious respiratory diseases other than TB. 60% of active TB group has high MBL level versus 13.3% of non-TB respiratory infection cases and 8.3% of noninfectious respiratory diseases group. Only one patient with far advanced tuberculosis showed significantly higher levels of MBL than patients with minimal and moderate disease while no significant difference seen between patients with minimal and moderately advanced diseases. Conclusion MBL is possibly related to increased susceptibility to tuberculosis. Its levels were nearly the same in both active and inactive tuberculous patients. There is a direct relation between levels of MBL and disease extensio

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