Introduction
Gall bladder carcinoma (GBC) continued to be a diagnostic and therapeutic challenge. Beside its rising incidence in the last years ,chronic cholecystitis is the most world wide gall bladder lesions , harboring many epithelial changes that may end in carcinoma .
Aim
This study aimed to investigate the expression of Her 2/neu , MUC1 and Ki-67 in malignant and non-malignant gall bladder lesions, and to evaluate its relation with clinicopathologic parameters of GBC
Material and Methods
This retrospective study included 40 cases of gall bladder carcinoma ,8 cases of gall bladder dysplasia, 10 cases of gall bladder metaplastic changes and 25 cases of chronic cholecystitis as a control group .The blocks were collected from the Pathology department of Benha University Hospital, from January 2012 to December 2019 . Immunohistochemical staining results of Her2/neu, Ki-67 and MUC1 were analyzed and correlated by SPSS version16 and Chi-square test or Fisher’s-exact tests.
Results
Positive her2/ neu expression (+2,+3) was detected in 47.5% (19/40) of malignant cases and 12.5% (1/8) of dyspastic group, in the same time it was completely absent in the metaplastic and cholecystitis cases (p |
