| You are in:Home/Publications/EVALUATION OF (PARP-1) EXPRESSION IN GASTRIC CARCINOMA BY IMMUNOHISTOCHEMISTRY AND QUANTITATIVE REAL-TIME PCR AND ITS RELATION TO HER2 STATUS. | |
Dr. Heba Mohamed Rashad :: Publications: |
|
| Title: | EVALUATION OF (PARP-1) EXPRESSION IN GASTRIC CARCINOMA BY IMMUNOHISTOCHEMISTRY AND QUANTITATIVE REAL-TIME PCR AND ITS RELATION TO HER2 STATUS. |
| Authors: | Marwa Said Abd Allaha , Heba mohammed Abd El Kariemb ,Heba Mohammed Rashada. |
| Year: | 2020 |
| Keywords: | Key Words: PARP-1, HER2, gastric carcinoma, Immunohistochemistry, Quantitative Real-Time PCR. |
| Journal: | The Medical Journal of Cairo University |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
Abstract: Background: PARP-1 overexpression has been identified in several malignancies. Few studies have handled the expression of PARP-1 protein in gastric carcinoma and its associations with outcome. This work aimed at exploring the significance of PARP-1 expression in gastric adenocarcinoma and correlation with HER2 status Methods: Quantitative expression of PARP-1 proteins was assayed by Immunohistochemistry in 40 cases of gastric adenocarcinoma. PARP-1 mRNA was moreover evaluated by Quantitative Real-Time Polymerase Chain Reaction. Results: The level of expression of mRNA expression level was significantly increased in 25 of 40 (62.5%) of gastric adenocarcinoma tissues compared with the corresponding adjacent non cancer tissues (P |
