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Dr. Hamasat Abd Elhafeez Abd Elkhalek Abd Elkader Elnoury :: Publications:

Title:
Cervical Cerclage for Pregnant Women at High-risk of Recurrent Preterm Birth can Act Beyond its Mechanical Action
Authors: Wagdy M. Amer1, Ali A. Morsi1, Hamasat A. Alnoury2
Year: 2023
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Hamasat Abd Elhafeez Abd Elkhalek Abd Elkader Elnoury_2.pdf
Supplementary materials Not Available
Abstract:

Aim: Evaluation of predictive value of levels of cervicovaginal fluid (CVF) interleukin (IL)-6 and 8, and matrix metalloproteinases (MMP) estimated at time of performing cervical cerclage (CC) in women with history of spontaneous preterm birth (SPTB) for pregnancy duration. Materials and Methods: 59 women had history of SPTB (Study group) and 25 women with no history of SPTB (Control group). Two CVF samples were obtained for ELISA estimation of IL-6, IL-8, MMP8 and MMP9 levels at 14-18 gestational weeks (GW), S1 sampling time, and at time of removal of CC suture, S2 sampling time. CC was applied 4-days after S1 sampling. Results: S1-CVF levels were significantly higher in study versus control women. S2-CVF levels were significantly higher in control, while were significantly lower in study women compared to S1 levels. S2-CVF IL-6 and IL-8 levels were nonsignificantly higher, while levels of MMP were significantly lower in study than control women. Percentages of change in cytokines' levels showed significant differences between study and control groups. Nineteen study women had PTD at 37 GW. Study women had significantly shorter CL and pregnancy duration compared to control women. Pregnancy duration was negatively correlated with percentage of CL change, while positively correlated with percentage of decrease of cytokines levels. Conclusion: CC induced significant decrease of CVF cytokines' levels and allowed prolongation of pregnancy duration for >37 GW in 67.8% of studied women at high risk of SPTB

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