Vancomycin-induced nephrotoxicity is characterized by acute tubular necrosis (ATN) or
interstitial damage (ATIN). Vancomycin-resistance among Enterococci has been escalating in recent
years in many countries. Linezolid (LNZ), an oxazolidinone is one of the novel drugs that promised
effective therapy of infections caused by vancomycin-resistant Enterococci (VRE). Objectives: The
present work aimed to experimentally compare the nephrotoxicity induced by linezolid and
vancomycin (VCM) on adult albino rat both biochemically and histopathologically. Methodology:
Thirty rats were randomly divided into three groups (10 rats each) Group (I) Control group, Group (II)
LNZ group and Group (III) VCM group. To study the toxic effect of linezolid on the kidney in
comparison with vancomycin. The level of serum creatinine, urea and malondialdehyde (MDA) were
measured. |
