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Prof. Evat Isaac :: Publications: |
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| Title: | Model Studies Related to Synthesis and 1, 4-Dipolar Cycloaddition Reactions of Mesoionic Heterocycles. |
| Authors: | Yvette Abd El-Sayed Issac |
| Year: | 1999 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
The reaction of 2-(substituted amino) pyridine with reactive malonic acid derivatives provided an extremely facile synthesis of the mesoionic compound 4-oxo-4H-pyrido [1, 2-a] pyrimidin-1-ium-2-olates. N, N′-Disubstituted amidine reacted with diethyl malonate to afford 4-quinolone in a one-pot cyclization and rearrangement (type A/I) of 4- oxopyridiniumolate 6. The latter compound was isolated via a reaction of acyclic amidine with AME's. A cycloaddition reaction of the mesoionic pyrimidine 6 with maleic anhydride ... |
