Background: Injuries involving skeletal muscle disturb millions across the globe.
Platelet-rich plasma (PRP) is encouraging strategy for improving tissue healing. Nigella
sativa (NS) have broad-spectrum therapeutic properties. Aim: The research assesses
the potential beneficial impact of PRP and NS on muscle injury. Materials and
Methods: 112 animals were allocated into five experimental groups: Group I, The
control group. Group II: administered only glycerol. Group III: administered glycerol
then PRP intramuscularly. Group IV: administered NS orally for 21days then glycerol.
Group V: given NS orally for 21days then glycerol then PRP. Half of the rats were
euthanized 7 days after glycerol injection (subgroups a) and the other half 14 days after
injection (subgroups b). H&E, Masson’s trichrome staining, myogenin
immunostaining, and ultrastructural analysis were performed on muscle sections.
Results: Group II exhibited destruction of myofibers and significant (P |
