Background: Cisplatin (CIS) is a powerful anti-neoplastic
medication, it has adverse effects including peripheral
neuropathy. Taurine (Tau) protects the cells by stabilizing
membranes, regulating calcium levels, antioxidant and
modulating apoptosis and inflammation. Objective:
evaluate the protective impact of Tau on peripheral
neuropathy caused by CIS. Materials and Methods: 45
healthy adult male albino rats spanning 150 to 250 grams
were indiscriminately assigned to four groups. Group I:
control group. Group II (CIS group): animals were
administered intraperitoneal (IP) injection of CIS at a
dosage of 2.5 mg/kg/day, with treatments biweekly
throughout four-weeks duration Group III (CIS+Tau): Four
days prior to the CIS injection, Tau was administered orally
by gavage (250 mg/kg/day), Tau then continued for four
weeks. Group IV (Tau group): Tau given orally (250 mg/
kg/ day) daily for four weeks. Sciatic nerve samples were obtained and prepared for light and electron microscopy
evaluation. Results: Group II showed disorganized nerve
bundle architecture and wide separation of nerve fibers.
Nuclei of Schwann cells (SC) were small and darkly stained
(pyknotic). Inflammatory cell infiltrate was observed. A
statically significant difference in collagen fiber deposition (P |
