Background: Androgenetic alopecia (AGA), a non-cicatricial type of hair loss, is the most frequent form of hair loss. It is marked by the increasing miniaturization of hair follicles (HFs) and a diminution of the cycle for hair growth. Purpose of the study: to evaluate the efficacy of botulinum toxin A versus mesotherapy with dutasteride versus PRP in the management of AGA. Patients and methods: 60 patients were diagnosed clinically and by dermoscope as AGA. They were split into three groups: Group I was treated with botulinum toxin A, an injection in the scalp (100 U/3 ml), for one session; Group II was treated with dutasteride intradermal injection in the scalp (0.005 mg/ml). Sessions were done (weeks 0, 1, 2, 3, 5, 7, and 11). Group III was treated with platelet-rich plasma (PRP) in one session every month for three months. All patients were assessed clinically (Ludwig and Sinclair classification) and by dermoscope at baseline and after 3 and 6 months of treatment. Results: There was no statistically significant difference between the studied groups regarding the Ludwig scale, Sinclair classification, and dermoscopic features at baseline and after 3 months (P > 0.05). However, after 6 months, a statistically significant difference was observed between the groups in the Ludwig scale (P = 0.06) and dermoscopic features, including hair diversity, vellus hair, yellow dots, and the peripilar sign (P < 0.05). Conclusion: All three treatment options are effective in reducing hair loss and increasing hair density to a variable extent after 6 months. |
