Objective to study the pharmacokinetic parameters of cefotaxime after repeated intramuscular injections in normal and experimentally Salmonella typhimurium infected goats. Cefotaxime was given at dose rate of 50 mg/kg b wt. three times daily for five consecutive days Plasma, milk and urine samples were collected. Cefotaxime level were estimated by microbiological assay. Plasma concentration revealed a lower significant concentration at all time sampling in Salmonella typhimurium infected goats than in normal goats. Maximum plasma concentration [Cmax] was significantly increase in normal than Salmonella typhimurium infected goats. Cefotaxime was cleared by all clearance processes (Cltot) in the body at significant faster rates in Salmonella typhimurium infected goats than in normal goats. The highest concentrations of cefotaxime in milk were recorded 4 hours after each intramuscular dose with a significant lower value in Salmonella typhimurium infected goats than in normal goats. The mean peak urine concentrations of cefotaxime were reached 2 hours after each intramuscular dose with a lower significant concentration in Salmonella typhimurium infected goats than in normal goats. The study indicated that cefotaxime was useful for treatment of Salmonella typhimurium infections. Key words: Pharmacokinetics, Cefotaxime, Goats. |
