Background: Pulmonary embolism is a potentially fatal medical condition. The objective of this study was to determine specificity and sensitivity of different echocardiographic parameters in PE and test the role of early systolic notch in predicting the side and localization of PE. Aim: This research investigated the diagnostic accuracy of different echocardiographic parameters and the role of early systolic notch in predicting side and localization of PE. Subjects Methods: This observational study was done in Benha University and Nasr City Hospitals, from August 2023 to March 2024. One-hundred and fifty patients were included to study the diagnostic accuracy of different echocardiographic parameters in PE. All subjects underwent history taking, clinical examination, Echocardiography and CTPA. Results: We included group (I) 67 patients with pulmonary emboli and group (II) 83 patients without pulmonary emboli in the study (mean age 65.54 ±11.14 years, 44.6% males). Patients of group I had significantly higher difference in D dimer, early systolic notch of pulsed wave across pulmonary valve, basal RV dimensions, Basal right ventricular/left ventricular ratio >1, Maconneell sign, 60/60 sign, Flattened inter ventricle septum, dilated IVC with collapsibility |