EVALUAT1ON OF SOME DRUGS IN EXPERIMENTAL CRYPTOSPORIDIOSIS
Samia M. Raslied; M.S. Younis; Aza S. El-Hamshari,
: Amina /. Abd El-Maboud, Department of Parasitology, Benha Faculty of Medicine. Egypt. J. Med. Sci. val 19. no. 2. 498 – 511(1998).
ABSTRACT
Cryptosporidium is a coccidian protozoan parasite of world wide distribution. Cryptosporidiosis was reported as an important cause of diarrhoea and gastroenteritis in humans. In man it is more frequent among children and immunocompromized individuals. It may be fatal in AIDS patients. A disease of such importance needs a curative treatment. Many trials of different drugs have been tried with limited success. We aimed at trying spiramycin. sulphadimethoxine and colchicine (not tried before) as sole agents and in different combinations in treatment of cryptosporidiosis in 240 immune-competent and immuno-suppressed mice. Assessment was done by stool examination using modified Ziehl- Neelsen technique and histopathological examination of the terminal ileum. Sulphadimethoxine proved effective in treatment of experimentally induced cryptospork|jal infection in mice. This was apparent in decreased oocyst count in stool and regression of histopathological changes. The curative effect was more
marked in immunocompetent than in immunosuppressed mice. Spiramycin was also effective as a treatment with similar results but to a lesser extent. Colchicine was not effective in treating experimentally induced cryptosporidiosis in mice as oocysts showed slight increase in count and aggravation of the histopathological changes. Combination of colchicine with spiramycin or sulphadimelhoxine gave results less effective than spiramycin or sulphadimethoxine separately.
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