Protective potency of imported commercial inactivated avian influenza virus vaccines were evaluated in chicks. After ensuring purity, safety and sterility of the used vaccines, their potency was evaluated in vaccinated chicks using Haemagglutination Inhibition (HI) test. HI antibody titers were increased gradually from 2nd week post vaccination till reached the peak at 4th week post vaccination, for all types of vaccine batches. HI antibody titers showed maximum titers varied from a batch to another and ranged from 7.8 to 8 log2 and 9.9 to 11.1 log2 for HVRI and YEBIO monovalent H5N1 vaccines, respectively. HI antibody titers were 8.0 log2 and ranged from 7.3 to 8.0 log2 for Boehringer Ingelhaim and Ceva monovalent H5N2 vaccines, respectively. HI antibody titers against avian influenza virus ranged from 7.3 to 7.5 log2 and 7.0 log2 for Boehringer Ingelhaim and Ceva bivalent avian influenza virus H5N2 plus Newcastle disease virus vaccines, respectively. Protection percent of vaccinated chicks 4 weeks post vaccination ranged from 81.9% to 90.9% and 90 % for HVRI and YEBIO inactivated monovalent influenza H5N1 vaccines, respectively. Protection percent ranged from 80 % to 88.9% and 81.8 % to 82.4% for Boehringer Ingelhaim and Ceva inactivated monovalent influenza H5N2 vaccines, respectively. Protection percent ranged from 80 % to 84.4% and 84.6 % to 100 % for Boehringer Ingelhaim and Ceva inactivated bivalent Avian Influenza H5N2 virus and Newcastle Disease virus vaccines, respectively. |
