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Prof. Asmaa Abd El Monem Hassan Hendawy :: Publications:

Title:
THERAPEUTIC EFFECT OF NITAZOXANIDE AND ZINGIBER OFFICINALE IN TREATMENT OF ACUTE TOXOPLASMOSIS GONDII USING MURINE EXPERIMENTAL MODEL
Authors: Mohammed HussienSaleh1; Amina Ibrahim Abdel–Maaboud1, Rabab Fawzy Mohammed Selem1, Hassan Ali Elfadaly2, AsmaaAbd El Monem El- Kholy1, Nagat Ahmed Soliman 1
Year: 2016
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Asmaa Abd El Monem Hassan Hendawy_paper 4.pdf
Supplementary materials Not Available
Abstract:

Toxoplasmosis is a cosmopolitan parasitic disease that impacts enormous population sector. In this work we investigated the antitoxoplamic therapeutic effect of one synthetic drug; nitazoxanide (NTZ) and another agent of plant origin; Zingiber officinale (ginger) as adjuvant to the traditional antotoxoplamic drugs (pyrimethamine & sulphadiazine) on experimental murine toxoplasmosis (RH virulent strain). Animals were classified into 7 groups; GI: Non-infected, non- treated (normal control), GII: Infected non -treated mice (infected control), GIII: Infected & treated by a combination of pyrimethamine & sulphadiazine (drug control), Group IV: Infected & treated by Zingiber officinale GV: Infected & treated by nitazoxanide, GVI: Infected & treated by combination of Zingiber officinale and pyrimethamine & sulphadiazine, Group VII: Infected & treated by combination of Zingiber officinale & nitazoxanide. For assessment of the therapeutic effect of various drug regimens on acute toxoplasmosis, survival rate and intraperitoneal fluid tachyzoite count were calculated. In the present study, Group VI achieved the best results among all studied groups so as to the survival rate increased to 70% and the tachyzoites count reduction rate was up to 72.9% as compared with the infected control mice. Inversely, group IV results were the lowest all over other groups with 20% survival and 33.3% tachyzoite reduction rates respectively. In between, the other groups lied in the grey zone and their corresponding measurements were as following: Group III, Group V and Group VII achieved 60%, 70%; 50, 58% and 40%, 55.5% for survival and tachyzoite reduction rates respectively. These results denote that nitazoxanide could be an acceptable, standardized, characterized, already FDA approved and commercially available substitute to traditional antitoxiplasmic synthetic drug. Also Zingiber officinale would be a safe and beneficial adjuvant treatment that potentiates the antitoxoplasmic action THERAPEUTIC EFFECT OF NITAZOXANIDE AND ZINGIBER OFFICINALE IN TREATMENT OF ACUTE TOXOPLASMOSIS GONDII USING MURINE EXPERIMENTAL MODEL By Mohammed HussienSaleh1; Amina Ibrahim Abdel–Maaboud1, Rabab Fawzy Mohammed Selem1, Hassan Ali Elfadaly2, AsmaaAbd El Monem El- Kholy1, Nagat Ahmed Soliman 1 1Medical Parasitology Department, Faculty of Medicine, Benha University, Egypt Medicine, Benha University, Egypt. 2Zoontic Diseases Department, National Research Center, (NRC), Egypt of the traditional treatment of toxoplasmosis. More studies are needed to address the dose response relationship of both NTZ and Zingiber officinale before using them for treatment of acute toxoplasmosis.

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