You are in:Home/Publications/An efficient synthesis of some new 1, 4-disubstituted phthalazine derivatives and their anticancer activity.

Prof. Ashraf Farouk :: Publications:

Title:
An efficient synthesis of some new 1, 4-disubstituted phthalazine derivatives and their anticancer activity.
Authors: Ashraf Farouk Wasfy, Aly Abdelmaboud Aly, Mohamed Sayed Behalo, and Nora Sobhi Mohamed
Year: 2013
Keywords: Not Available
Journal: Der Pharma Chemica
Volume: 5
Issue: 2
Pages: 82-96
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Not Available
Supplementary materials Not Available
Abstract:

A novel series of phthalazine derivatives bearing isoindol-1,3-dione moiety were synthesized by treating ethyl{4-[4- (1,3-dioxo-1,3-dihydroisoindole-2-yl)-phenyl] phthalazin-1-yloxy}acetate (3) and {4-[4-(1,3-Dioxo-1,3- dihydroisoindol-2-yl)phenyl]phthalazin-1-yloxy} acetic acid hydrazide (7a) with various chemical reagents.The newly synthesized compounds were characterized on the basis of their spectral (1H NMR, 13C NMR, Ms, IR) analyses. In vitro, most of the synthesized derivatives were screened for their antitumor activity against MCF-7 cells using MTT assay. Compounds 16b, 18, 13, 15, 17 showed the most potent cytotoxic effect concluded from their IC50 values 50, 70, 150, 180 and 100 μg/ml respectively.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus