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Dr. Amira Emam Ahmed Emam Khalil :: Publications:

Title:
Pregnancy-Associated Placental Protein A2/Placental Growth Factor Ratio Might Discriminate Normotensive Pregnant Women Who Are Liable to Develop Early-Onset Preeclampsia
Authors: Heba E. Abdel Raziq1 , Amira E. Khalil1 , Hamasat A Alnoury2,4*, George N.B. Morcos3,4, Moataz Maher Kamel3,4
Year: 2023
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Amira Emam Ahmed Emam Khalil_EJCHEM_Volume 66_Issue 13_Pages 371-377.pdf
Supplementary materials Not Available
Abstract:

Objectives: Evaluation of the ability of serum Pregnancy-associated Placental Protein A2 (PAPP-A2), Placental growth factor (PLGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels estimated at the 12th gestational weeks (GW) to predict the possibility of development of preeclampsia (PE) in the normotensive pregnant women. Patients: 66 PE and 66 No-PE women gave blood samples at the 12th GW for ELISA estimation of study biomarkers. During pregnancy, 21 women had early-onset and 19 women had severe PE. Study outcome is the ability of serum cytokines' levels estimated at the 12th GW for prediction of oncoming PE development. Results: Blood pressure (BP) measures were significantly higher in PE women than their baseline measures and corresponding measures of women of No-PE group. Serum levels of PAPP-A2 and sFlt-1 were significantly higher, while levels of PLGF were significantly lower in PE than in No-PE women. ROC curve analysis defined PAPP-A2/PLGF ratio >0.51 as discriminator point for early-onset PE with moderate accuracy (AUC=0.662; 95% CI: 0.264-0.982) and sensitivity rate of 90.48% and negative predictive value of 94.12%. Conclusion: Determination of PAPP-A2/PLGF ratio in serum at the 12 GW might be used as early predictor for PE and ratio at >0.51 could predict early-onset PE with moderate accuracy.

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