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Ass. Lect. Amal Ghonemy Metwali Abo Zekry :: Publications:

Title:
A comparative Study Between The Therapeutic Role of Bone Marrow Mesenchymal Stem Cells and That of Histamine2 Receptor Antagonists (Nizatidine) in The Management of Ibuprofen Induced Gastric Ulcer in Adult Albino Rats
Authors: Amal Ghonaimy Metwally , Saadia Ahmed Shalaby , / Essam Mohamed Ibraheem , Osama Fouad Ahmed , Samia Mahmoud Manawy.
Year: 2020
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Amal Ghonemy Metwali Abo Zekry_anatomy paper 2.pdf
Supplementary materials Not Available
Abstract:

Introduction: One of the widely used gastro protective agents are H2 receptor antagonists (H2RAs). But these drugs may induce several adverse effects. Recent studies have shown that mesenchymal stem cells (MSCs) play an important role in the healing of gut injuries. Aim of the work: To evaluate the role of bone marrow- mesenchymal stem cells (BM- MSCs) in the treatment of gastric ulcer, and to compare their efficacy with H2RAs therapy. Methods: 10 out of the 50 adult albino rats used in this study were served as donors for stem cells and the other 40 rats were divided into four groups: Group I (control group). Group II (Gastric ulcer group), rats received 200mg /kg ibuprofen suspended in CMC-Na 1% given orally by gastric tube. Group III (Nizatidine treated group ), rats with gastric ulcer were treated with 31.25 mg/kg nizatidine ,given orally by gastric tube. Group IV(BM-MSCs treated group),rats with gastric ulcer were injected with BMMSCs in the rat tail vein. Results: MSCs-treated group revealed improvement of histological structure and restoration of the normal architecture of the gastric mucosa. Nizatidine-treated group demonstrated nearly similar results to that of MSCs treated group. A significant decrease of tumor necrosis factor α (TNF-α) expression was observed in MSCs-treated group as well as nizatidine-treated group when compared to ulcer group (P

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