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Prof. almotawaly abdelbasat :: Publications:

Plasma Alpha Gluthione-S-Transferase In Patients With Chronic Viral Hepatitis
Authors: Fawzy Mugahid, Metwally Zakaria Abdel Baset, and Mahmoud El Azzoni
Year: 2000
Keywords: Not Available
Journal: Tanta Medical Journal
Volume: 28
Issue: 1
Pages: 100-125
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Not Available
Supplementary materials Not Available

alpha-Glutathione S-transferase (alpha-GST; EC has been advocated as a better marker of hepatocellular damage than the transaminases in toxic and autoimmune hepatitis. We have assessed the potential interest of plasma alpha-GST determination in 94 anti-hepatitis C virus-positive patients with histologically proven chronic hepatitis C (34 women, 60 men, ages 40.0 +/- 11.9 years). Blood samples were assayed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase, alkaline phosphatase, and alpha-GST on the same day a liver biopsy was performed. alpha-GST concentrations were significantly above reference values in 64% of patients (compared with 58% for AST, 68% for ALT), and this increase was seen in 52% of patients with normal values for transaminases and a Knodell score > 3. Furthermore, there was a significant correlation between alpha-GST and lobular necrosis score (r = 0.31; P < 0.01). Our findings suggest that association of plasma alpha-GST with ALT may improve the biochemical assessment of liver damage in patients with chronic hepatitis C.

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