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Prof. Ahmed Abdel-ٍSalam Khalil :: Publications: |
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| Title: | Utility of 4-(isatin-3-ylideneamino) benzohydrazide in the synthesis of bioactive N-heterocyclic compounds. |
| Authors: | MMH Arief, AA Aly, AA Khalil, HI Mohamed |
| Year: | 2014 |
| Keywords: | Not Available |
| Journal: | Journal of Chemical & Pharmaceutical Research |
| Volume: | 6 |
| Issue: | 2 |
| Pages: | 327-335 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Ahmed Abdel-ٍSalam Khalil_Mohamed M. H. Arief_JCPR-2014-6-2-327-335.pdf |
| Supplementary materials | Not Available |
| Abstract: |
4-(Isatin-3-ylideneamino) benzoic acid, was synthesized and converted into 4- (isatin-3-ylideneamino) benzoyl chloride. Hydrazinolysis of the acid chloride afforded4- (isatin-3-ylideneamino) benzohydrazide. The latter compound was used as a key precursor for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and oxadiazole derivatives via its reaction with different electrophilic reagents. Structures of all synthesized compounds were elucidated from FT-IR, 1H-NMR, mass spectroscopy and elemental analyses. |
