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Dr. Ahmed Mohamed Hussein :: Publications:

Title:
Telomerase Activity in Diabetic Patients with Angiopathy
Authors: 1Ayman El Badawy,1 Mohamed Shawky,1Amr M. ElHammady,1Mohamed El-Assal,1Ashraf Talaat ,1Ahmed M.Hussein, 1,2Khalid Belal
Year: 2014
Keywords: telomerase, diabetic patients, angiopathy (micro- or macroangiopathy).
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Ahmed Mohamed Hussein_telomerase.pdf
Supplementary materials Not Available
Abstract:

Diabetes mellitus (DM) is associated with damage to target organs and premature aging and telomeres serve as a mitotic clock and biological marker of senescence. Aim of study: was to A) evaluate telomerase activity in both type 1 and type 2 diabetic patients with microangiopathy and macroangiopathy, B) to study the possible factors that affect the activity of this enzyme in these patients. Subjects and Methods: Study was carried out on 40 patients from those attending diabetes clinics of Banha University Hospital, they were divided into three groups: Group I: 10 type 1 diabetic patients with angiopathy (4males & 6 females). Group II: 10 type 2 diabetic patients with angiopathy (3males & 7females). Group III: 20 apparently healthy age & sex matched volunteers serving as a control group. The following laboratory investigations were performed to all patients: Plasma glucose (fasting and post prandial), Glycated hemoglobin, Lipogram (Total cholesterol, LDLc, HDLc and Triglycerides), Serum creatinine, Urinary microalbumin and Study of telomerase activity in whole blood. Results: Our results showed: that (HBA1C, microalbumin, creatinine, LDL, TG, TCH, PPBS and FBS)are significantly higher in diabetic patients compared to control group where (telomeraseand HDL) are significantly lower in diabetic patients compared to control group. Also, Telomerase activity was significantly low in diabetic patients with HbA1C (≥7%), LDL-c (>100mg/dl), HDL-c (150mg/dl), TCH (>200mg/dl), microalbuminuria (>30mg/ml) respectively compared to diabetic patients with HbA1C (

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